Experienced IVF doctors in Delhi state that there have been numerous inventions and discoveries made that have culminated into various tests and analysis that can now help determine how healthy the embryos are and the condition of the chromosomes in them. This analysis can help predict if the IVF cycle will be successful and whether the embryos will be able to implant or not.
Over the past two decades, many such tests have surfaced. Some have been very precise, others not so. Some of these tests include:
FISH or Fluorescence in Situ Hybridization – one of the first methods of genetic testing, this cytogenetic procedure involves staining the embryo cells with fluorescent ink to help differentiate between the DNA in the cell and the rest of it. The ink binds itself or stains only the DNA of the cell and this helps analyze the DNA patterns and more to decipher whether the embryo carries any genetic disorders or diseases in its genes.
PGD or Preimplantation Genetic Diagnosis – this procedure involves the scanning and analysis of embryo cells that allows the doctors to get their hands on any embryo that has defective chromosomes especially if the parents have a genetic disorder or disease that runs in the family. In this way, the embryos that are free of any defects and are perfectly healthy are transferred into the mother's womb.
CCS or Comprehensive Chromosome Screening – similar to Preimplantation Genetic Diagnosis, this procedure helps decipher the number of chromosomes in an embryo cell. If the embryo cell is euploid or consists of an equal and normal amount of chromosomes, it becomes safe to be transferred into the mother's womb. An excessive or low number of chromosomes make the chances of miscarriage higher.
NGS or Next generation sequencing – also known as high-throughput sequencing, this procedure involves multiple DNA analyzing or sequencing techniques that together examine the DNA sequences or patterns in a cell to establish whether the embryo is healthy or not.
According to doctors in top IVF hospitals in Delhi, the problem are that these tests may be contemporary and highly revealing, yet they cannot 100 percent determine whether the IVF treatment will be successful or not. Albeit, these tests do well to determine as much as possible about the state of the embryo's DNA; however, the information they provide still is not sufficient to predict the accomplishment or failure of an IVF treatment. Furthermore, it is unfortunate that a large number of doctors prescribe these tests to IVF patients even after knowing that they would not really prove to be helpful for them.