The greatest advantages of blastocyst transfer is the capability to decrease the risk of multiple pregnancy by transferring fewer embryos of larger quality. We have had a small percentage of transferring smaller embryos of better quality. We have received a very small extent of triplet pregnancies from blastocyst transfer at our clinic. The triplet rates with blast transfers at IVF center have been around two percent of pregnancies. The triplet has around always been because of same twin classification of an embryo.
Two transferred and three implanted subsequent single embryo has split into two.
In the early stage of blastocyst transfer observed at embryos early on fifth day and had patients with slower embryo growth introduced in sixth day for their transfer. For instance, patients with solely morula stage embryos and no actual blastocyst still.
It was assumed better to allow those slower embryos grow and flourish more in the culture dish prior selecting the best single or double for transfer.
Although success rate data of blastocyst transfer for sixth day were slightly smaller that were observed for fifth day transfer. It is trusted that it is because few embryos that are slighter on fifth day are of poor quality or faint. Undoubtedly the slow embryos that had blastocyst growth on sixth day and went on to develop hatch, implant and give birth to strong and healthy babies with only slighter beginning.
Evaluating fifth and sixth day blastocyst transfers, better success rates have been received with transfer made on fifth day. Although, it is particularly because patients with embryos growing at a more general rate were receiving embryo transfers performed on fifth day, not because implanting embryos on sixth day is poor for result.
Blastocyst culture and fifth day embryo transfer for in vitro fertilization permits choice of the excellent quality embryo for implantation. Embryo quality is essential with infertility. With blastocyst transfer, only some embryos – decreasing the level of pregnancy and retain successful IVF. The IVF success rate depends upon the age of a woman and quality of her eggs.
What is Blastocyst Embryo Transfer technique
- An embryo that has grown for five to seven days subsequent to fertilization and has two unlike cells and a mid cavity filled with fluid.
- The blastocyst cells have right exactly begun to differentiate.
- The surface cells that cover the cavity are known as trophectoderm and will later grown into placenta.
- A more centrally produced group of cells – internal cell mass will grown into fetus
- Blastocyst normally creates on fifth day as fluid creates inside the constricted morula.
- A well grown blastocyst usually starts hatching from external shell, known as zona pellucia between fifth to seventh day of fertilization.
- Within one day subsequent to hatching, embryo transfer through IVF starts as embryo occupies the uterus lining.
- An HCG hormone is released by blastocyst that leaks into mother's blood with after implantation of embryo.
Blastocyst production rate:
- The objective of in vitro fertilization and embryo culture is to offer great quality embryos that have potential of consistent growth and provide live births
- Although in the standard IVF culture conditions, just around 25 to 60 percent of human embryos develop to the blastocyst level after five days of culture.
- The small pace of embryo growth is caused by :
a. Less than required culture condition in the lab dish
b. The inherent weakness of child embryos
This is the reason that in old times, embryos were transferred to uterus within two to three days.
Benefits of blastocyst transfer for IVF
- An issue with above is that two to three day old embryos are usually in the fallopian tubes instead the uterus. The embryo enters to uterus after eighty hours of ovulation.
- Embryo implantation procedure starts after three days of blastocyst production and hatching out of the embryo shell have occurred.
- Hence if in vitro culture dish environments are extended to produce healthy blastocysts at the large rate, in this case fifth day blastocyst embryo transfer can be performed.
- Transfer of blastocyst after IVF also enhances the pregnancy rate while decreasing the rate of multiple pregnancies.
- By culturing embryos until fifth day often to helps in identifying which of them couldn't become blastocyst and help in conducting a possible pregnancy.
- Transfer of fewer and healthy embryos ensure high pregnancy rate while extremely slight risk of multiple foetus development.